Basic and clinical studies on biapenem in obstetrics and gynecology

Abstract

Basic and clinical studies on biapenem (BIPM), a newly-developed parenteral carbapenem antibiotic, were performed, and the following results were obtained.
1. The concentration of BIPM in serum and internal genital organs after intravenous drip infusion of 300mg were examined.
The peripheral serum level was 10.6μg/ml at 15 minutes, decreasing to 2.11μg/ml (mean) at about 2.5 hours.
Although there were some variation among sex organs, the concentration in the tissues was 2.05-4.42±g/g at 15 minutes and 0.18-0.40μg/g at about 3hours after administration.
2. The concentration of BIPM in serum and retroperitoneal fluid after intravenous drip infusion of 300mg were examined. The concentration in retroperitoneal fluid were 8.67 ± 1.69μg/ml at 15 minutes, decreasing to 0.46 ± 0.21μg/ml at 6.5hours after administration.
3. In a clinical trial, BIPM was administered to 10 patients with obstetric and gynecological infections (6 cases of parametritis, 1 of puerperal intrauterine infection, 1 of salpingitis, 1 of pyometra and 1 of infectious lymphocystitis).
The results were as follows: 7 cases were judged as good and 3 poor. The efficacy rate was 70%, Bacteriologically, 16 organisms were isolated from 9 patients. The iradication rate was 87.5%(14/16).
No side effects and abnormal laboratory findings were observed in any of the cases.
Hence it appears that BIPM will be a very useful antibiotic in obstetric and gynecologic infections.