Clinical study on biapenem in respiratory tract infections

Abstract

A clinical study on biapenem (BIPM), a new carbapenemn antibiotic for injection, in the treatment of respiratory infections were performed.
Eight patients with acute pneumonia and one patient with bronchiectasis were treated with BIPM with their own consent. BIPM was given intravenously in a daily dose of 300-600mg by drip infusion for 14-15days, with the total administrated dose ranging from 8.4 to 18grams.
Clinical efficacy was rated as excellent in 2, good in 7. With regard to the bacteriological effects, all of the eight strains isolated from 5 patients were eliminated by the administration of BIPM. As side effects, mild diarrhea occured in one patient on the 6th day after the treatment, however, the patient could easily tolerated to continuation of the treatment. Increase of platelet count were observed in one patient but it was transient.