1994 Volume 42 Issue Supplement4 Pages 769-772
Biapenem (BIPM) was administered to five patients, two with septicemia, one with infected bronchiectasis, one with pulmonary tuberculosis and one with infected cystic kidney, at a dose of 300mg twice daily for 3 to 20.5 days through intravenous drip infusion.
Clinical response was excellent in one (septicemia), good in two (septicemia and infected bronchiectasis). Pulmonary tuberculosis and infected cystic kidney with slight symptoms and signs of inflammation were excluded from the clinical evaluation.
Two strains of Escherichia coli, which were identified as causative organism in each case with septicemia, were eradicated after biapenem treatment.
Slight and transient elevation of GOT, GPT and LDH in one case, and that of GOT, GPT, ALP, γ-GTP and LAP in one case were noted. No subjective or objective adverse reaction was observed in all cases.
