Antibacterial activity of grepafloxacin against fresh clinically isolates gram-positive bacteria

Abstract

To investigate antibacterial spectrum and antibacterial activity of grepafloxacin (GPFX), MICs of GPFX as well as other antibiotics were determined against standard strains of gram-positive and grampositive bacteria clinically isolates obtained in 1993.
The results obtained are summarized as follows:
1. Antibacterial high activity of GPFX was suggested by MICs against gram-positive bacteria. MIC₉₀ of GPFX against methicillin (DMPPC)-resistant Staphylococcus aureus subsp. aureus, and benzylpenicillininsensitive or-resistant Streptococcus pneumoniae was lowest as compared with reference drug. It was studied that MIC of GPFX against ofloxacin-resistant strains of DMPPC-susceptible S. aureus and Corynebacterium spp. were going up, and suggested that fluoroquinolone-resistant gram-positive bacteria could get cross resistance to GPFX.
2. As antibacterial activity of GPFX against gram-positive bacteria was high, suggesting that it was selected antibiotic at first in community-acquired infection.