Abstract
The in vitro and in vivo antibacterial activities of pazufloxacin (PZFX) against streptococci were compared with those of quinolones and -cephems.
The antibacterial activity of PZFX against Streptococcus pneumoniae isolated from clinical materials was inferior to tosufloxacin (TFLX) and ciprofloxacin (CPFX), similar to ofloxacin (OFLX), and superior to norfloxacin (NFLX) and fleroxacin (FLRX). Against penicillin susceptible S. pneumoniae, it was inferior to cefaclor (CCL). Against penicillin insensitive and resistant S. pneumoniae, it was superior to CCL. The antibacterial activities of PZFX against Streptococcus pyogenes and Streptococcus agalactiae were inferior to those of TFLX, CPFX and OFLX, and superior to those of NFLX and FLRX.
The bactericidal activities of PZFX against penicillin susceptible and resistant S. pneumoniae were similar to other quinolones, which depended on drug concentration.
The therapeutic effects of PZFX on systemic infection and experimental pneumonia in mice caused by penicillin susceptible and resistant S. pneumoniae were inferior to those of TFLX, but similar to those of OFLX. The therapeutic effects of PZFX against these infections caused by penicillin resistant S. pneumoniae were superior to those of cefixime. These results reflected approximately the MICs of each antimicrobial agents.
