Abstract
In order to examine the transfer of quinolones to inflammation focus, the concentrations of pazufloxacin (PZFX), ofloxacin (OFLX) and ciprofloxacin (CPFX) were measured using subcutaneous disk model, tissue cage model and CMC pouch model. In disk implanted model, the concentration of PZFX in disk was nearly proportional to the serum concentration. Although the half life of PZFX in transdate was shorter than that of OFLX, the Cmax of PZFX at the focus was higher than that of OFLX. In tissue cage model and CMC pouch model, the exudate levels of PZFX were higher than those of OFLX and CPFX. The therapeutic effects of PZFX against the single infection with Pseudomonas aeruginosa and mix infection with P. aeruginosa and Staphylococcus aureus at inflammation focus were superior to those of OFLX and CPFX because of its potent antibacterial activities and high concentrations in the focus.
