Abstract
1. Minimum inhibitory concentrations (MICs)(inoculum size 104 CFU/well) of pazufloxacin (PZFX), ofloxacin (OFLX), and tosufloxacin (TFLX) were determined against 62 isolates of Staphylococcus aureus from skin and skin structure infections. PZFX showed a peak of MIC distribution at 1μg/ml (34 isolates), OFLX at 1μg/ml (28 isolates), and TFLX at 0.06μg/ml (32 isolates).
2. Serum and skin concentrations of PZFX after a single oral administration of PZFX (20 mg/kg) were determined in rats. Mean serum concentrations were 2.34, 3.76, 2.29, 0.74μg/ml, and corresponding skin concentrations were 1.20, 2.84, 1.92, 0.90 μg/g at 0.5, 1, 2, 4 hours after the drug administration, respectively.
