Abstract
Since quinolones have been reported to have potent convulsant activity, we studied the effect of pazufloxacin (PZFX) on the receptor binding of γ-aminobutyric acid (GABA). PZFX hardly inhibited GABA receptor binding in its high concentration (10-3M). And non-steroidal anti-inflammatory drugs did not affect the inhibitory activity of PZFX. And the intraventricular injection of PZFX induced convulstion in mice in its high doses, and concurrent administration of 4-biphenylacetic acid (5 nmol) did not affect the convulsant activity of PZFX. These results suggest that PZFX might have very weak convulsant activity.
