テレフタール酸の血漿内サイアミン濃度に及ぼす影響 1. 血漿内サイアミン濃度増加及び持続性

榑谷 和男; 星 昭夫; 平山 八彦

doi:10.2508/chikusan.36.511

Effect of Terephthalic Acid on Plasma Thiamine Level

I. Elevation of Plasma Thiamine Level and Its Duration

Kazuo KURETANI, Akio HOSHI, Yatsuhiko HIRAYAMA

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JOURNAL FREE ACCESS

1965 Volume 36 Issue 12 Pages 511-514

DOI https://doi.org/10.2508/chikusan.36.511

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Published: December 25, 1965 Received: April 14, 1965 Available on J-STAGE: March 10, 2008 Accepted: - Advance online publication: - Revised: -
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Date of correction: March 10, 2008 Reason for correction: - Correction: ABSTRACT Details: Wrong : Tetracycline-type antibiotics were potentiated by terephthalic acid (TPA) and the ac-celeration of body growth was observed in the fowl ¹, ⁴, ⁹-¹¹). Further, the TPA contained diet without antibiotics has the same effect on faccilitation of body weight gain and the feed conversion ratios were lowered in the fowl ⁵, ⁶). From these interesting function of TPA, we-planned to clarify how TPA effects on the plasma nutrient's concentration. In this study, plasma thiamine contents were determined.
Control group (25 fowls) was fed with the basal diet and TPA group (25 fowls) was fed with the diet containing TPA (0.5%) for 20 days. Followed by the oral administration of thiamine (1mg/kg of body weight), blood was collected from the carotid with a heparinized. syringe at 0, 4th, 24th and 48th hour, from 10, 5, 5 and 5 fowls respectively. Blood was. centrifuged and plasma was used for thiamine determination.
Thiamine level in each case is tabulated in Table 1. The increased rate of TPA group, was 1.7 times higher at 4th hour and 3.7 times higher at 24th hour than control group. The increased thiamine content by administration of the control group successively decreased and reached normal level at 48th hour, but that of TPA group was kept still higher. After all, it is studied that the plasma thiamine level in all cases of TPA group were higher than that:of control group.
This effect of the TPA was observed not only in the fowl but also in the rat. The increased rate of TPA group was 1.4 times higher at 4th hour and 3.0 times higher at 24th hour than control group (Table 2).
In conclusion, plasma thiamine level in the TPA group of the fowl was elevated and kept for 48 hours by single administration of thiamine and this elevation was also occured in the rat.
Biological half-lives of thiamine (per os) in control and TPA groups were estimated, but significant difference was not observed (Fig. 1). This result suggests that the primary mechanism of TPA's effect on the elevation of plasma thiamine content seems to be concerned with the absorption of thiamine across the gastrointestinal wall rather than with the kidney threshold for the excretion of thiamine.
Right : Tetracycline-type antibiotics were potentiated by terephthalic acid (TPA) and the ac-celeration of body growth was observed in the fowl ^{1, 4}, ⁹-¹¹⁾. Further, the TPA contained diet without antibiotics has the same effect on faccilitation of body weight gain and the feed conversion ratios were lowered in the fowl ^{5, 6)}. From these interesting function of TPA, we-planned to clarify how TPA effects on the plasma nutrient's concentration. In this study, plasma thiamine contents were determined.
Control group (25 fowls) was fed with the basal diet and TPA group (25 fowls) was fed with the diet containing TPA (0.5%) for 20 days. Followed by the oral administration of thiamine (1mg/kg of body weight), blood was collected from the carotid with a heparinized. syringe at 0, 4th, 24th and 48th hour, from 10, 5, 5 and 5 fowls respectively. Blood was. centrifuged and plasma was used for thiamine determination.
Thiamine level in each case is tabulated in Table 1. The increased rate of TPA group, was 1.7 times higher at 4th hour and 3.7 times higher at 24th hour than control group. The increased thiamine content by administration of the control group successively decreased and reached normal level at 48th hour, but that of TPA group was kept still higher. After all, it is studied that the plasma thiamine level in all cases of TPA group were higher than that:of control group.
This effect of the TPA was observed not only in the fowl but also in the rat. The increased rate of TPA group was 1.4 times higher at 4th hour and 3.0 times higher at 24th hour than control group (Table 2).
In conclusion, plasma thiamine level in the TPA group of the fowl was elevated and kept for 48 hours by single administration of thiamine and this elevation was also occured in the rat.
Biological half-lives of thiamine (per os) in control and TPA groups were estimated, but significant difference was not observed (Fig. 1). This result suggests that the primary mechanism of TPA's effect on the elevation of plasma thiamine content seems to be concerned with the absorption of thiamine across the gastrointestinal wall rather than with the kidney threshold for the excretion of thiamine.

Date of correction: March 10, 2008 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: March 10, 2008 Reason for correction: - Correction: ABSTRACT Details: Wrong : Tetracycline-type antibiotics were potentiated by terephthalic acid (TPA) and the ac-celeration of body growth was observed in the fowl ¹, ⁴, ⁹-¹¹). Further, the TPA contained diet without antibiotics has the same effect on faccilitation of body weight gain and the feed conversion ratios were lowered in the fowl ⁵, ⁶). From these interesting function of TPA, we-planned to clarify how TPA effects on the plasma nutrient's concentration. In this study, plasma thiamine contents were determined.
Control group (25 fowls) was fed with the basal diet and TPA group (25 fowls) was fed with the diet containing TPA (0.5%) for 20 days. Followed by the oral administration of thiamine (1mg/kg of body weight), blood was collected from the carotid with a heparinized. syringe at 0, 4th, 24th and 48th hour, from 10, 5, 5 and 5 fowls respectively. Blood was. centrifuged and plasma was used for thiamine determination.
Thiamine level in each case is tabulated in Table 1. The increased rate of TPA group, was 1.7 times higher at 4th hour and 3.7 times higher at 24th hour than control group. The increased thiamine content by administration of the control group successively decreased and reached normal level at 48th hour, but that of TPA group was kept still higher. After all, it is studied that the plasma thiamine level in all cases of TPA group were higher than that:of control group.
This effect of the TPA was observed not only in the fowl but also in the rat. The increased rate of TPA group was 1.4 times higher at 4th hour and 3.0 times higher at 24th hour than control group (Table 2).
In conclusion, plasma thiamine level in the TPA group of the fowl was elevated and kept for 48 hours by single administration of thiamine and this elevation was also occured in the rat.
Biological half-lives of thiamine (per os) in control and TPA groups were estimated, but significant difference was not observed (Fig. 1). This result suggests that the primary mechanism of TPA's effect on the elevation of plasma thiamine content seems to be concerned with the absorption of thiamine across the gastrointestinal wall rather than with the kidney threshold for the excretion of thiamine.
Right : Tetracycline-type antibiotics were potentiated by terephthalic acid (TPA) and the ac-celeration of body growth was observed in the fowl ^{1, 4}, ⁹-¹¹⁾. Further, the TPA contained diet without antibiotics has the same effect on faccilitation of body weight gain and the feed conversion ratios were lowered in the fowl ^{5, 6)}. From these interesting function of TPA, we-planned to clarify how TPA effects on the plasma nutrient's concentration. In this study, plasma thiamine contents were determined.
Control group (25 fowls) was fed with the basal diet and TPA group (25 fowls) was fed with the diet containing TPA (0.5%) for 20 days. Followed by the oral administration of thiamine (1mg/kg of body weight), blood was collected from the carotid with a heparinized. syringe at 0, 4th, 24th and 48th hour, from 10, 5, 5 and 5 fowls respectively. Blood was. centrifuged and plasma was used for thiamine determination.
Thiamine level in each case is tabulated in Table 1. The increased rate of TPA group, was 1.7 times higher at 4th hour and 3.7 times higher at 24th hour than control group. The increased thiamine content by administration of the control group successively decreased and reached normal level at 48th hour, but that of TPA group was kept still higher. After all, it is studied that the plasma thiamine level in all cases of TPA group were higher than that:of control group.
This effect of the TPA was observed not only in the fowl but also in the rat. The increased rate of TPA group was 1.4 times higher at 4th hour and 3.0 times higher at 24th hour than control group (Table 2).
In conclusion, plasma thiamine level in the TPA group of the fowl was elevated and kept for 48 hours by single administration of thiamine and this elevation was also occured in the rat.
Biological half-lives of thiamine (per os) in control and TPA groups were estimated, but significant difference was not observed (Fig. 1). This result suggests that the primary mechanism of TPA's effect on the elevation of plasma thiamine content seems to be concerned with the absorption of thiamine across the gastrointestinal wall rather than with the kidney threshold for the excretion of thiamine.

Date of correction: March 10, 2008 Reason for correction: - Correction: PDF FILE Details: -

Abstract

Tetracycline-type antibiotics were potentiated by terephthalic acid (TPA) and the ac-celeration of body growth was observed in the fowl ^{1, 4}, ⁹-¹¹⁾. Further, the TPA contained diet without antibiotics has the same effect on faccilitation of body weight gain and the feed conversion ratios were lowered in the fowl ^{5, 6)}. From these interesting function of TPA, we-planned to clarify how TPA effects on the plasma nutrient's concentration. In this study, plasma thiamine contents were determined.
Control group (25 fowls) was fed with the basal diet and TPA group (25 fowls) was fed with the diet containing TPA (0.5%) for 20 days. Followed by the oral administration of thiamine (1mg/kg of body weight), blood was collected from the carotid with a heparinized. syringe at 0, 4th, 24th and 48th hour, from 10, 5, 5 and 5 fowls respectively. Blood was. centrifuged and plasma was used for thiamine determination.
Thiamine level in each case is tabulated in Table 1. The increased rate of TPA group, was 1.7 times higher at 4th hour and 3.7 times higher at 24th hour than control group. The increased thiamine content by administration of the control group successively decreased and reached normal level at 48th hour, but that of TPA group was kept still higher. After all, it is studied that the plasma thiamine level in all cases of TPA group were higher than that:of control group.
This effect of the TPA was observed not only in the fowl but also in the rat. The increased rate of TPA group was 1.4 times higher at 4th hour and 3.0 times higher at 24th hour than control group (Table 2).
In conclusion, plasma thiamine level in the TPA group of the fowl was elevated and kept for 48 hours by single administration of thiamine and this elevation was also occured in the rat.
Biological half-lives of thiamine (per os) in control and TPA groups were estimated, but significant difference was not observed (Fig. 1). This result suggests that the primary mechanism of TPA's effect on the elevation of plasma thiamine content seems to be concerned with the absorption of thiamine across the gastrointestinal wall rather than with the kidney threshold for the excretion of thiamine.

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