Abstract
In order to clarify the changes of the Krebs cycle occurring in myocardium working under conditions of anoxia, the capacities of oxidizing various substrates related to the cycle were studies in myocardial homogenates removed from rats killed after exposure to low pressure (310 mmHg) and CO-poisoning.As the method of the experimental CO-poisoning, the method of the intraperitoneal CO-administration inaugurated by T. Ishikawa in experiments on mouse and rabbits, was applied on a rat. For measuring the oxidizing capacity of a tissue, the Thunberg-tube was employed and the methylenblue decoloring time was assessed, to which the sodium salt, respectively, of lactate, pyruvate, citrate and succinate was added as substrates.
