Abstract
EXPERIMENTAL RENAL HYPERTENSION The author produced experimental renal hypertension in twenty adult dogs, 7.0-17.2 kg. weight, using the method of Goldblatt (12 dogs) and Page (8 dogs). Blood pressure was messured 2 to 3 times a week with the direct puncture in the femoral artery. In the course of this experiment, it was performed the clinical examination including the measurement of body weight, urinary volume and electrocardiogram. After the animals were sacrificed, the author examined organs histopathologically, with special reference to the relation of observed histological alternations to hypertension.The Results of this study were as follows : 1. Generally, the more pronounced the elevation of blood pressuer, the more marked the lesion in kidneys. However, in some of the cases, pronounced elevation occured in animals whose renal lesion was slight. To the contrary, in some cases elevation in blood pressure was minimal in the presence of moderately pronounced renal lesion. It seems that there exists no definite relation between the hypertension, it degree and duration, and the renal lesion.2. There was no lineary proportinal relation between the degree of renal lesion and the time allowed after the performance of the operation.3. There was no such relation that the hypertensive dog with excretory renal failure necessarily showed pronounced vascular lesion.4. Exudation in glomeruli, presumbly caused by abruptly developing pronounced hypertension, occured in small number of the case.5. There existed no relation of linear proportion between the degree of hypertrophy of the heart and the degree of hypertension or length of time allowed after the institution of the operation.6. Generally, the more pronounced the elevation in blood pressure, the more extensive the injuried area.
