Abstract
Four different rabbit groups of Masugi nephritis were made : group with Masugi nephritis, group with Masugi nephritis previously treated with ACTH, cortisone and unilateral adrenalectomy. The picture of serum and urine protein were investigated electrophoretically and the changes of kidneys and adrenals were observed histopathologically and histochemically. From results obtained, authors concluded that the picture of serum and urine protein presented very similar findings to human nephrotic syndrome or nephronephritis in previously treated rabbits and from the histopathological changes we think to have proved that disharmony of adrenal function caused the change of glomerulitis and marked increase of pathological change in tubuli, and disharmony of pituitary-adrenocortical system participates in the genesis of nephrotic syndrome.
