Abstract
The effects of plasmin and anti-plasmin on an experimental cerebrovascular occlusion were observed in dogs. It was suggested that plasmin would inhibit the progress of local ischemic changes by enhancing collateral circulation when used in an early stage of the disease, but it would merely increase the risk of hemorrhage when used in the cases where vascular changes have already developed. Ipsilon treatment after the occlusion apparently reduced angionecrotic changes and hemorrhagic tendency at the affected area, indicating a marked suppressing effect for the local hyperplasmic state due to the vascular occlusion.
