Quantum-biological Analysis of the Relation of Urea and its Related Compounds to Water in Renal Medulla

抄録

The intramolecular negative formal charges of urea, methylurea, acetamide, 1-3-dimetylurea and thiourea were calculated by Simple-Linear-Combination of Atomic-Orbital and Molecular-Orbital Method. Then, these charges were divided by (molecular radius)^2-3 or (MR-D)^2-3. By this calculation, a new index showing the intensity of negative charge around the molecule was obtained. The order of the magnitude of these indices agreed well with that of ability to enhance urinary osmolality or water reabsorption in renal medulla of dogs shown by RABINOWITZ et al, and that of the accumulation strenghth of these substances into the renal medulla in anti-diuretic low-protein rats shown by TRUNIGER et al.