Abstract
1) Tubular transport of sulfonamide compound occurs in a bidirectional manner; that is, both unconjugated and acetylated sulfonamide compound are secreted in the proximal segment and reabsorbed in the distal segment of the kidneys. The site of sulfonamide compound secretion is approximately identical with that of PSP or PAH secretion and the site of reabsorption lies between the sites of Na reabsorption and K secretion. 2) It is suggested that sulfonamide compounds are actively secreted in the proximal segment, and that for distal reabsorption an active transport and a partly diffusion mechanism are involved.
