Effect of Angiotensin II on Renal Hemodynamics and Urinary Excretion of Sodium and Potassium in the Rat

抄録

Effect of angiotensin II on the renal hemodynamics and electrolytes excretion were studied with a clearance method in rats. Intraperitoneal administration of angiotensin II reduced RPF and GFR. The hemodynamic effect of angiotensin II was disappeared following adrenalectomy, and partially restored DOC or cortisone. Angiotensin II increased a urine flow and an excretion of Na with slight de-crease In an excretion of K. But, It showed no such effect in adrenalectomized rats. DOC or cortisone restored the action of angiotensin II on the excretion of electrolytes in adrenalectomized rats. Adrenal cortex hormone may play an important role on the action of angiotensin II on the renal hemodynamics and renal tublar cells in rats.