Pathophysiological Studies Blood Gas Partial Pressure and pH in Various Diseases.

Abstract

This paper consists of the following two sections. Section 1 : Blood gas partial pressure and pH in various diseases. Section 2 : Blood gas partial pressure and pH according to disease conditions. Purpose of the Studies: Blood gas and pH which are the results of systemic and various organic circulation and metabolism have, conversely, great influences on the organic circulation and metabolism. Since the fairly accurate determination of blood gas partial pressure and pH became possible, there have appeared reports on the blood gas partial pressure and pH determined in individual patients. There has, however, been no report on studies based on simultaneous determination of PaO₂, PaCO₂, and pH in various diseases. In view of the above mentioned lack of re-port, the present author carried out studies on the general features observed according to diseases on hospital admission of the patients. Those studies are presented in Section I of this paper. Further studies along the above line but according to the conditions in various diseases (relatively normal state, dyspneic state, and serious state accompanied by clouded conscious-ness) are presented in Section 2. The studies are calculated to contribute to the diagnosis of disease conditions and to the formulation of guidelines for their treatment. Methods and Materials Arterial blood O₂ partial pressure (PaO₂) and arterial blood carbon dioxide partial pressure (PaCO₂) were determined with an I-L meter. pH was also determined. Bicarbonate ion (HC O₃^-) was calculated by the HENDERSON-HASSEL-BACH formula. Subjects: Since the determinations were done at or near the patients' admission, subjects of various conditions were included in the present studies, numbering 210 cases in all, consisting of 26 healthy subjects, 56 patients with pulmonary diseases, 55 with cardiac diseases, 18 with renal diseases, 42 with hepatic diseases, and 13 with diabetes.