Abstract
Possibility was shown in the previous experiment that a relatively small amount of a certain derivative of Benzoylcarbinol (B.C.T.) when administered into rats with profound hypertension produced by renal ischemia, would display a suppressive effects on the development of widespread arterial lesions. The present experiment was carried out to obtain the further knowledge of useful dose of the drug to make such a effect. Daily administration of 10mg of B.C.T., as well as 25mg, der Kg of body weights into the renal hypertensive rats was more effective than that of 5mg or 100mg. Significant increase in number of the hypertensive rats without vascular lesions was found in group of either 10mg or 25mg of B.C.T. but not in group of Anginin (Antibradykinin). And also the severity and extent of damaged arteries seen in the splanchnic organs and the heart tended to be decreased in group of the same dose of B.C.T.
