Control of Renin Secretion in the Anesthetized Dog 2) Relationship between Renin Secretion, Plasma Sodium Concentration and GFR in the Perfused Kidney

Abstract

Renin secretion was investigated in the perfused dog kidney with an artificial heart-lung apparatus. Renin secretion from the perfused kidney was markedly increased following a quick reduction of sodium concentration in the perfusion plasma by 4 to 11 mEq/L. A reduction of sodium concentration in the perfusion plasma increases renin secretion through a decrease of GFR. Renin secretion rate was apparently related to GFR inversely (r=-0.728, P<0.01), and less related to sodium excretion (r=0.331, 0.05<P<0.1).