Myocarditis Induced by Sympathomimetic Amines (I)
1970 年 34 巻 1 号 p. 7-12
詳細
1970 年 34 巻 1 号 p. 7-12
Production of myocardial lesions with sympathomimetic a mines was studied in rats. Subcutaneous administration of isoproterenol at the daily doses of 1.2mg and 0.7mg per kg for 14 days caused a marked diffuse myocarditis. The myocardial lesions were detected by electrocardiogram 1 week after the begin-ning of the administration. Norepinephrine, nor-fenefrine and phenylephrine did not show any pathologic change in the myocardium. The significance of the toxic effects of these a mines was studied.
