1973 Volume 36 Issue 12 Pages 1435-1445
In an attempt to elucidate pathophysiology of hypertensive intracerebral hemorrhage, the changes of the blood pressure were studied in relation to prognosis, localization or volume of hematoma, elapsed time from attack, and pressure of cerebrospinal fluid in the patients with hypertensive intracerebral hemorrhage. The changes of plasma serotonin content and blood pressure were also studied in the dogs with experimental intracerebral hemorrhage. In the patients the localization of hematoma either assumed by ultrasonic diagnosis, cerebral angiography and neurological examination, or confirmed by operation or autopsy. An experimental intracerebral hemorrhage was produced by destruction in the brain of the dogs with reversible mass pressing method. The destructive lesion was produced by the balloon which was inserted into the brain through a small perforation drilled on the skull and inflated with an air rapidly. In both clinical and experimental cases, localization of hematoma was classified into the four group according to Scheinker's classification. The blood pressure on stroke were measured within 1 hour from attack in all patients. In the clinical research the following results were obtained: 1. Blood pressure on stroke was 160-300/90-150 mmHg, and had descended with the lapse of time. 2. On stroke, blood pressure in lateral type was higher than that in combined type or pontine hemorrhage, and the difference of blood pressure in these types disappeared gradually. 3. On stroke, there was no close relation between systolic pressure and prognosis, while the prognosis in cases with extreme low diastolic pressure was unfavorable. 4. There was no relation between blood pressure and volume of hematoma or the pressure of cerebrospinal fluid.
