Abstract
^3H-norepinephrine (NE) disappearance rate after the intraventricular injection of 3H-NE tended to be delayed in the brainstem but not in the telencephalon of spontaneously hypertensive rats (SHR) in the prehypertensive stage, while these indices were conversely accelerated in the heart and slightly so in the kidney of SHR. A similar tendency was partially noted in the brainstem, telencephalon and heart of SHR, DOC and renal hypertensive rats at the age of 10 weeks which had maintained hypertension for 1 month. The relative delay in the NE turnover of the brainstem compared with telencephalon was seemingly the common deviation of NE metabolism in these rats with genetic or experimental hypertension.
