1973 年 37 巻 3 号 p. 297-303
The cardiotoxicities produced by a continuous infusion of desacetyl-lanato-side C (deslanoside) alone in guinea pigs were definitely suppressed by concomitant infusion of a beta-adrenoceptor blocking agent, alprenolol (aptin, H56/28). However, the antagonistic potency of alprenolol was smaller than that of propranolol, although according to the literatures the potency of beta-adrenoceptor blocking activity of the former was said to be no less than that of the latter. That is, the correlation between the antagonistic potency against deslanoside-induced cardiotoxicities and the potency of beta-adrenoceptor blocking activity of alprenolol did not run parallel in contrary to that of propranolol. It seems probable that the suppressive activity of alprenolol against deslanoside-induced cardiotoxicities is not based on the specific action on the beta-adrenoceptor.
