Hypertensive Vascular Lesions and Renin or Lysosomal Enzymes in Rats

抄録

1) In rats treated with DOCA plus high salt or with high salt alone, hypertensive rats with renal vascular lesions showed an incomplete suppression of KRA. Cathepsin activity of rat kidney was higher under high salt loading than in the control. Beta-glucuronidase activity was greatest in rats with renal vascular lesions and smallest in rats fed on normal chow. RNase and DNase activities were greater in rats with renal vascular lesions than in rats without renal vascular lesions under high salt loading. 2) In rats of both sexes SHR showed greater KRA and cathepsin activities than WK rat under high salt loading. In female rats DNase, RNase and β-GPase activities were greater in SHR than in WK rat under high salt loading. 3). KRA was higher in SHRSP aged 10 months than in SHRSR, though KRA of SHR was smaller than KRA of WK rat. Cathepsin activity was greater in SHRSP than in SHRSR. DNase and β-NAGA activities were greater in SHR than in WK rat . 4) In 7 weeks of age SHRSR showed more PRC than SHRSP. At the age of 10 months SHRSP showed higher PRC than WK rat. The roles of renin and lysosomal enzymes in hypertensive renal vascular lesions were discussed to some extent. (This research is sponsored by the Science and Technology Agency of Japanese Government.)