EFFECTS OF VERAPAMIL ON SA AND AV NODAL ACTION POTENTIALS IN THE ISOLATED RABBIT HEART

TATEHIKO OKADA; TOMOTSUGU KONISHI

doi:10.1253/jcj.39.913

JAPANESE CIRCULATION JOURNAL

Online ISSN : 1347-4839
Print ISSN : 0047-1828
ISSN-L : 0047-1828

EFFECTS OF VERAPAMIL ON SA AND AV NODAL ACTION POTENTIALS IN THE ISOLATED RABBIT HEART

TATEHIKO OKADA, TOMOTSUGU KONISHI

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Keywords: SA node, AV node, Atrial muscle, Verapamil, Calcium ions

JOURNAL FREE ACCESS

1975 Volume 39 Issue 8 Pages 913-917

DOI https://doi.org/10.1253/jcj.39.913

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Abstract

In the isolated rabbit heart, it was shown that verapamil suppressed the electrical activities of the SA and AV nodes without preventing regenerative responses in atrial muscle fibers. It was concluded that the different effects of verapamil on SA and AV nodal action potentials resulted from the operation of a different ionic channel (slow channel) from that of ordinary atrial muscle.

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