EFFECT OF EDTA2Na IN CONTRAST MEDIA ON HEMODYNAMIC AND ELECTROCARDIOGRAPHIC CHANGES DURING SELECTIVE CORONARY ANGIOGRAPHY : An Experimental Study

Abstract

The contrast media used contains 10-40 mg/dl of EDTA2Na as stabilizer, and its effect on cardiac contraction during selective coronary angiography was studied experimentally. When EDTA2Na was added to the blood, the Ca⁺⁺ was almost completely chelated at levels of more than 80 mg/dl. EDTA2Na was added to 10ml of blood at varying concentrations and injected into the LAD artery of laboratory dogs, and the changes related to the concentration were observed in regard to the left ventricular pressure, max.dp/dt/ P, cardiac output, contraction in the LAD area and the LCF area, and ECG. There was observed no marked reduction in the LAD area was marked. When the concentration was over 60 mg/dl, paradoxical systolic expansion began to appear. Depending on the concentration of EDTA2Na, the QT interval was prolonged and the ventricular extra systole increased in frequency; ventricular fibrillation occurred in 16% of the dogs at 60 mg/dl, in 68% at 80 mg/dl and in all the dogs at 100 mg/dl. This study demonstrates that the administration of EDTA2Na produces significant transient changes in ECG and cardiovascular function and that it is one of the factors involved in these changes observed during selective coronary angiography with angiographic agents containing EDTA2Na.