1980 年 43 巻 12 号 p. 1059-1071
This study was made to determine whether patients with coronary artery disease have any specific abnormality in their serum lipoprotein pattern which might be a factor in the etiology of the disease. Serum lipoproteins (Lps) of 18 patients with myocardial infarction (group A), 28 patients with other forms of coronary artery disease (group B), and 22 healthy control subjects (group C) were studied using ultracentrifugal and electrophoretic techniques. All subjects were Japanese living in Japan. Acrylamide gel electrophoresis of the patients' sera showed, in addition to bands of α- and β-globulin and pre-β-lipoprotein mobility, one of mobility between that of β and pre-β-mobility, mid-band. It was present in 100% of sera of group A, 93% of group B but only 50% of group C. The midband is a subfraction of the LDL fraction isolated by ultracentrifugation at d 1.006 to 1.063. The midband may be resolved as a single, double or multiple band fraction on acrylamide gel. By ultracentrifugation subfractions of LDL were detected in 16 of 18 patients in group A (89%), 10 of 13 patients in group B (77%) and 3 of 11 in group C (27%), respectively. Of LDL subfractions Sf 10 LDL was most frequent; in 77% of group A's sera, and 89% of group B's, Sf 10 was the sole or major subfraction. Serum HDL, determined ultracentrifugally was significantly lower (p 0.01) in group A and B (179.3 14.3, and 219.1 20.3, mean SE) than in group C persons (319.9 16.7). The above findings indicate that accumulation of Sf 10 LDL and other LDL subfractions may occur in association with a decrease of HDL in atherosclerotic coronary artery disease. It is suggested that those abnormalities may contribute to the genesis of atherosclerotic coronary artery disease.
