1981 Volume 45 Issue 12 Pages 1335-1341
A basic study was conducted on the method for the determination of thiobarbituric acid-reactive substances (TBARS) produced by platelets. Some modifications were introduced which enabled a precise semimicrodetermination. The average values of platelet TBARS production in hypertensives and in patients with cerebral infraction were higher than that in healthy controls. Among patients with cerebral infraction, those with angiographically demonstrated obstruction of internal carotid or middle cerebral arteries showed an increased production as compared with non-obstructive cases. These results may suggest the important role of platelet arachidonate metabolism in obstructive cerebrovascular disorders.
