Effects of Chronically Administered Atrial Natriuretic Factor in Aldosterone-Infused Hypertensive Rats : SYMPOSIUM ON ATRIAL NATRIURETIC POLYPEPTIDE (ANP): Basic and Clinical Research : 51th Annual Scientific Session of the Japanese Circulation Society

Abstract

To assess the pathophysiological role of atrial natriuretic factors in mineralocorticoid hypertension, we studied the effects of chronic infusion of synthetic atrial natriuretic factor on blood pressure and sodium-water excretion in rats with aldosterone salt-induced hypertension. Administration of synthetic atrial natriuretic factor (150 μg/kg/day) to rats made hypertensive by 7-day infusion of aldosterone (100 μg/kg/day) and sodium loading with 1% NaCl as drinking water returned the blood pressure to control levels, and the anti-hypertensive effect was not associated with any changes in urine volume and urinary sodium excretion. These results indicate that atrial natriuretic factors may be involved in the regulation of blood pressure in mineralocorticoid hypertension, independent of the renal effects of these substances.