1991 年 55 巻 11 号 p. 1144-1148
To address unresolved questions, experimental models of viral myocarditis may be of great value. In this study, immunological mechanisms of myocardial dam-age in coxsackievirus B3 myocarditis in mice were investigated. The results showed that susceptibility to viral infection is primarily determined by the gene-tic background of the host, that the severity of myocarditis depends not upon B cells but upon T cells, and that antigen-specific T cells play a pivotal role in the pathogenesis of acute coxsackievirus B3 myocarditis.