Author's Organization:Third Department of Intemal Medicine, Chiba Unjversity School of Medicine Third Department of Intemal Medicine, Chiba Unjversity School of Medicine Third Department of Intemal Medicine, Chiba Unjversity School of Medicine Third Department of Intemal Medicine, Chiba Unjversity School of Medicine Third Department of Intemal Medicine, Chiba Unjversity School of Medicine