Abstract
Chromosomal analysis of leukocytes was performed on cleft lip and/or cleft palate patients(probands),separating them into isolated cases and multiple-occurring cases.
Chromosome abnormalities, including heteromorphisms, were found in 5 cases out of 43 multip occurring cases (11.6 %). There were no cases with certain chromosome aberrations in the 66 isolated ca except for one suspicious case.
The cause of the high i n cidence of chrorosome abnormalities in the multiple-occurring cases is not de Since the type of aberrations observed were variable, they may not be directly related to the etiology clefting.
