Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843

This article has now been updated. Please use the final version.

Effects of Statin Intensity on Clinical Outcome in Acute Myocardial Infarction Patients
Doyeon HwangHyun Kuk KimJoo Myung LeeKi Hong ChoiJihoon KimTae-Min RheeJonghanne ParkTaek Kyu ParkJeong Hoon YangYoung Bin SongJin-Ho ChoiJoo-Yong HahnSeung-Hyuk ChoiBon-Kwon KooYoung Jo KimShung Chull ChaeMyeong Chan ChoChong Jin KimHyeon-Cheol GwonMyung Ho JeongHyo-Soo KimThe KAMIR Investigators
Author information
JOURNAL FREE ACCESS FULL-TEXT HTML Advance online publication
Supplementary material

Article ID: CJ-17-1221

Details
Abstract

Background:There has been debate regarding the added benefit of high-intensity statins compared with low-moderate-intensity statins, especially in patients with acute myocardial infarction (AMI).

Methods and Results:The Korea Acute Myocardial Infarction Registry-National Institutes of Health consecutively enrolled 13,104 AMI patients. Of these, a total of 12,182 patients, who completed 1-year follow-up, were included in this study, and all patients were classified into 3 groups (no statin; low-moderate-intensity statin; and high-intensity statin). The primary outcome was major adverse cardiac event (MACE) including cardiac death, non-fatal MI, and repeat revascularization at 1 year. Both low-moderate-intensity and high-intensity statin significantly reduced low-density lipoprotein cholesterol (LDL-C; all P<0.001). Compared with the no statin group, both statin groups had significantly lower risk of MACE (low-moderate intensity: HR, 0.506; 95% CI: 0.413–0.619, P<0.001; high intensity: HR, 0.464; 95% CI: 0.352–0.611, P<0.001). The risk of MACE, however, was similar between the low-moderate- and high-intensity statin groups (HR, 0.917; 95% CI: 0.760–1.107, P=0.368). Multivariable adjustment, propensity score matching, and inverse probability weighted analysis also produced the same results.

Conclusions:When adequate LDL-C level is achieved, patients on a low-moderate-intensity statin dose have similar cardiovascular outcomes to those on high-intensity statins.

Content from these authors
© 2018 THE JAPANESE CIRCULATION SOCIETY
feedback
Top