てんかん発作を主徴とした自己免疫性脳炎の臨床的特徴と早期治療におけるスコアリングの有用性の検討

種本 真将; 鈴木 秀一郎; 横川 和樹; 齋藤 太郎; 岩原 直敏; 津田 玲子; 渡邊 修; 高橋 幸利; 米田 誠; 久原 真

doi:10.5692/clinicalneurol.cn-001911

Original Articles

Clinical characteristics of seizure-predominant autoimmune encephalitis and utility of anti-neuronal antibody scores for early treatment

Masanobu Tanemoto, Syuuichirou Suzuki, Kazuki Yokokawa, Taro Saito, Naotoshi Iwahara, Reiko Tsuda, Osamu Watanabe, Yukitoshi Takahashi, Makoto Yoneda, Shin Hisahara

Author information

Masanobu Tanemoto
Department of Neurology, Sapporo Medical University, School of Medicine
Syuuichirou Suzuki
Department of Neurology, Sapporo Medical University, School of Medicine
Kazuki Yokokawa
Department of Neurology, Sapporo Medical University, School of Medicine
Taro Saito
Department of Neurology, Sapporo Medical University, School of Medicine
Naotoshi Iwahara
Department of Neurology, Sapporo Medical University, School of Medicine
Reiko Tsuda
Department of Neurology, Sapporo Medical University, School of Medicine
Osamu Watanabe
Department of Neurology, Kagoshima City Hospital
Yukitoshi Takahashi
Department of Clinical Research, NHO, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
Makoto Yoneda
Faculty of Nursing and Social Welfare Sciences, Fukui Prefectural University
Shin Hisahara
Department of Neurology, Sapporo Medical University, School of Medicine

Keywords: autoimmune encephalitis, epilepsy, APE² score, ACES score, antibody

JOURNAL OPEN ACCESS FULL-TEXT HTML

2024 Volume 64 Issue 4 Pages 272-279

DOI https://doi.org/10.5692/clinicalneurol.cn-001911

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Details

Abstract

We analyzed 20 patients diagnosed with autoimmune neurological diseases with seizure predominance. In these patients, we examined the usefulness of Antibody Prevalence in Epilepsy and Encephalopathy (APE²) score and Antibodies Contributing to Focal Epilepsy Signs and Symptoms (ACES) score in autoimmune encephalitis (AE) for facilitating early treatment. APE² score was positive in 19 of 20 patients. ACES score was positive in 15 of 20 patients, and 4 of 5 of the patients with negative ACES score did not have AE. Comprehensive assessment including the use of the above scores is desirable in the early stage of AE.

Corresponding author

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