Abstract
Heating of 1-oxides of 2-(N-acetoacetyl) pyridinesulfonamide, 4-methyl-2-(N-acetoacetyl) pyridinesulfonamide, 4-(N-acetoacetyl) pyridinesulfonamide, and 4-(N-acetoacetyl)-quinolinesulfonamide each in 10% sodium hydroxide at 90∼95°causes rearrangement reaction with liberation of sulfur dioxide to form respectively, 2-pyridineacetic acid, 1-oxides of 4-methyl-2-pyridineacetic acid, 4-pyridineacetic acid, and 4-quiolineacetic acid. These substances were confirmed by their respective decarboxylation and derivation to 2-picoline 1-oxide, 2, 4-lutidine 1-oxide, 4-picoline 1-oxide, and lepidine 1-oxide.
