Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 15,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University
Read more
28,149 registered articles
(updated on September 27, 2023)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
2022 Journal Impact Factor (JIF)
Scopus Pubmed
Featured article
Volume 71 (2023) Issue 9 Pages 687-694
Effects of Granulated Lactose Characteristics and Lubricant Blending Conditions on Tablet Physical Properties in Direct Powder Compression Read more
Editor's pick

This study evaluated the effects of different forms of granulated lactose (GL) on the physical properties of tablets and the effect of magnesium stearate on each type of GL. The different forms of GL such as agitated granulation (GL-AG), spray-dried granulation (GL-SD), and fluidized bed granulation (GL-FB) were added as excipients during direct powder compression. When tablets with the same blending conditions were compared, the tensile strength and disintegration time followed the order as GL-FB > GL-SD > GL-AG. The authors presented selection criteria for the suitability of different forms of GL during tableting by examining the relevance between the type of GL and properties of the tablets produced.

Volume 71 (2023) Issue 9 Pages 701-716
Synthesis and Evaluation of Novel Triaryl Derivatives with Readthrough-Inducing Activity Read more
Editor's pick

Readthrough therapy, which restores the biosynthesis of full-length proteins by incorporating an amino acid at a premature termination codon and allowing translation to continue, has recently been actively investigated for its application to nonsense mutation-related diseases. In this article, triaryl derivatives were synthesized and evaluated for the development of novel readthrough agents to treat mucopolysaccharidosis type I, which is caused by nonsense mutations in the IDUA gene. KY-516, a representative compound, exhibited excellent readthrough-inducing activity in the luciferase assay and significantly increased enzyme activity in mutant IDUA transgenic cells.

Volume 71 (2023) Issue 9 Pages 717-723
Synthesis of New 26,27-Difluoro- and 26,26,27,27-Tetrafluoro-25-hydroxyvitamin D3: Effects of Terminal Fluorine Atoms on Biological Activity and Half-life Read more
Editor's pick

In this Article, the authors investigated the effects of fluorine atoms introduced to the terminal positions of the side chain (26 and 27-positions) of 25-hydroxyvitamin D3 (25(OH)D3) on vitamin D receptor (VDR) binding affinity, osteocalcin promoter transactivation activity, and levels of resistance against CYP24A1-dependant metabolism. They revealed that these biological activities were enhanced in the order of 26,27-difluoro, 26,26,27,27-tetrafluoro, and 26,26,26,27,27,27-hexafluoro-25(OH)D3. Introduction of fluorines at these positions lead to improvements on functions as VDR-ligands and biological activity. With regard to the VDR binding affinity, the authors considered those potency improvements might be attributed to the increased acidity of the 25-OH group.

Volume 71 (2023) Issue 9 Pages 730-733
Synthesis and in Vitro Cytotoxicity Evaluation of Jadomycins Read more
Editor's pick

The authors synthesized jadomycins and their structural analogues, evaluated their cytotoxic activity, and addressed structure-activity relationship study of jadomycins. They achieved the total synthesis of jadomycin T and jadomycin aglycons using L-threonine and 1-amino-2-propanol as nitrogen sources. When the cytotoxicity of jadomycins were evaluated in several tumor cells, the jadomycin aglycons tended to be more cytotoxic than the jadomycins. The authors also demonstrated the potential application of jadomycins as lead compounds for the treatment of brain tumors. This paper provides important insights into the total synthesis of other natural organic compounds, structure-activity relationship studies, and development of new therapeutic drugs.

View all featured articles
View all articles in current issue
Most viewed articles (August 2023)
Share this page
Browse by volume and issue
Announcements from publisher
  • Chem. Pharm. Bull. Vol. 71 No. 7
    Current Topics: Development of Naturally Occurring Compounds for the Treatment of Intractable Diseases
  • Chem. Pharm. Bull. Vol. 71 No. 6
    Current Topics: In Silico Technologies to Boost Pharmaceutical Development
  • Announcement of Academic Journals’ Awards Chemical and Pharmaceutical Bulletin (CPB)
  • Chem. Pharm. Bull. Vol. 71 No. 2
    Current Topics: Transition Metal Catalysis Research in Pharmaceutical Organic Chemistry
  • Chem. Pharm. Bull. Vol. 71 No. 1
    Current Topics: Applications of Fluorescence Detection in Current Pharmaceutical Research