Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Ken-ichi Hosoya
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

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27,095 registered articles
(updated on January 23, 2018)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Featured article
Volume 66 (2018) Issue 1 Pages 84-95
Solid-Phase Modular Synthesis of Park Nucleotide and Lipids I and II Analogues Read more
Editor’s picks

The paper describes solid-phase synthesis of peptidoglycan biosynthesis precursor and its analogues: Park nucleotide (1), neryl-lipid I (2) and neryl-lipid II (3). The higher acidity of activators accelerated the reaction rate of diphosphate formation, and solid-phase diphosphate formation was accomplished by using triazolium triflate (29) as an activator. The synthetic strategy enables to prepare 1-3 in a short time with a single purification. These analogues could be useful as chemical probes for discovering novel antibacterial agent and elucidating mechanistic studies.

Volume 66 (2018) Issue 1 Pages 78-83
Secoiridoid Glycosides from the Twigs of Ligustrum obtusifolium Possess Anti-inflammatory and Neuroprotective Effects Read more
Editor’s picks

This study showed that secoiridoid glycosides are the main constituents of the twigs of L. obtusifolium, and two new secoiridoid derivatives, obtusifoliside A and B (1, 2), were isolated from this plant. Moreover, anti-inflammatory, and neuroprotective activities of the isolated compounds were investigated. Among the isolates, the new compound 2 showed remarkably better anti-inflammatory effects without cell toxicity. This study could be useful for the development of novel anti-inflammatory and neuroprotective agents.

Volume 66 (2018) Issue 1 Pages 20
Foreword Read more
Editor’s picks

Technological progress in medicinal chemistry has contributed to develop a variety of drug candidates in pharmaceuticals. Focusing on the significant progress in the fields shown in the cover, the present current topics include three reviews, “New Gateways to Platinum Group Metal-Catalyzed Direct Deuterium-Labeling Method Utilizing Hydrogen as a Catalyst Activator,” “7-Azaindole: A Versatile Scaffold for Developing Kinase Inhibitors” and “Discovery and Development of Muscarinic Acetylcholine M4 Activators as Promising Therapeutic Agents for CNS Diseases” and one communication, “A Peptide–Glycolipid Interaction Probed by Retroinverso Peptide Analogues.”

Volume 66 (2018) Issue 1 Pages 1-19
Creation of Novel Toxic Gas Surrogates and the Development of Safe and Facile Catalytic Reactions Read more
Editor’s picks

Utilization of toxic gas surrogates can contribute to improving the safety and practicality for implementation of synthetic organic reactions. This review describes the author’s discovery, development, and applications of toxic gas surrogates. Various carbonyl compounds were obtained by Pd-catalyzed carbonylative transformations under mild conditions using novel carbon monoxide (CO) surrogates. Mechanistic studies of the CO generation and gram-scale syntheses using CO surrogates were successfully performed. Furthermore, the use of an inexpensive sulfur dioxide surrogate led to the development of unprecedented selective syntheses of sulfonamides and sulfinamides.

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Journal news & Announcements
  • Coming soon
    Current Topics: Medicinal and Bioorganic Chemistry of Nucleosides and Nucleotides

  • Chem. Pharm. Bull. Vol. 66 No. 1
    Current Topics: Recent Progress in Medicinal Chemistry