Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Ken-ichi Hosoya
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama



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27,268 registered articles
(updated on November 16, 2018)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
1.258
2017 IMPACT FACTOR
JOURNALS PEER REVIEWED FREE ACCESS FULL-TEXT HTML ADVANCE PUBLICATION
Featured article
Volume 66 (2018) Issue 11 Pages 1019-1022
In Vitro Synergism and Anti-biofilm Activity of Quercetin–Pivaloxymethyl Conjugate against Staphylococcus aureus and Enterococcus Species Read more
Editor’s picks

Quercetin-pivaloxymethyl conjugate (Q-POM) potentiated the activity of ampicillin, cefepime, and vancomycin against S. aureus and Enterococcus (including highly resistant strains such as hVISA, VISA, and VRE), by decreasing the MICs of these antibiotics by 4-128 folds. Q-POM was found to be partially synergistic with ampicillin and cefepime against S. aureus and Enterococcus, while it was strongly synergistic with vancomycin. Q-POM at 5 mg/L inhibited the formation of biofilms of S. aureus by 24-83% and VRE by 70%. Additionally, Q-POM inhibited the hemolytic activity of S. aureus in a dose-dependent manner.

Volume 66 (2018) Issue 11 Pages 1041-1047
Urea Insertion Reaction of Rhodium-Carbenoid Read more
Editor’s picks

Metal carbenoid species are known to insert into a C−H bond, C=X double bonds (X = C, N, O), and Y−H bonds (Y = N, O, Si, P, S, etc), however, a carbenoid insertion into a urea C−N bond has not yet been reported. In the article, the first urea insertion reaction of carbenoid species is described. The urea insertion reaction proceeded smoothly using Rh2(NHPiv)4, a rhodium catalyst previously designed by the authors’ group, to produce highly functionalized bridged molecules with three adjacent stereocenters.

Volume 66 (2018) Issue 11 Pages 1048-1056
Scale-Up Procedure for Primary Drying Process in Lyophilizer by Using the Vial Heat Transfer and the Drying Resistance Read more
Editor’s picks

Primary drying conditions for the commercial manufacturing were designed based on the vial heat transfer coefficient of the production lyophilizer and the drying resistance (Rp) calculated from manufacture with the pilot lyophilizer under dust-free condition. The production scale-verification study confirmed that the Rp obtained using pilot lyophilizer under dust-free condition could be available for the production lyophilizer. This scale-up theory, which bridges the gap between the laboratory scale and the production scale, is useful for the development of an efficient and robust process at production scale.

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Journal news & Announcements
  • Chem. Pharm. Bull. Vol. 66 No. 5
    Current Topics: Natural Products Chemistry of Global Tropical and Subtropical Plants




  • Chem. Pharm. Bull. Vol. 66 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future

  • Chem. Pharm. Bull. Vol. 66 No. 2
    Current Topics: Medicinal and Bioorganic Chemistry of Nucleosides and Nucleotides



  • Chem. Pharm. Bull. Vol. 66 No. 1
    Current Topics: Recent Progress in Medicinal Chemistry



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