Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 15,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics, which then merged the Journal of Health Science, another former Society’s journal, in 2012. It covers various biological topics in the pharmaceutical and health sciences. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English. The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, scientific communication, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Hidehiko Nakagawa
Graduate School of Pharmaceutical Sciences, Nagoya City University

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28,282 registered articles
(updated on July 20, 2024)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
2022 Journal Impact Factor (JIF)
Scopus Pubmed
Featured article
Volume 72 (2024) Issue 6 Pages 524-528
Theoretical Study of Natural Product Biosynthesis Using Computational Chemistry Read more
Editor's pick

In recent years, research on the natural product biosynthesis using computational chemistry has been actively pursued, leading to significant advancements in understanding complex biological processes. This review provides an in-depth overview of a number of studies conducted by the authors, focusing particularly on terpene compounds. These studies not only contribute to the fundamental knowledge of natural product biosynthesis but also hold potential applications in drug discovery, agriculture, and biotechnology. The insights gained from these investigations pave the way for future research in this rapidly evolving field.

Volume 72 (2024) Issue 6 Pages 529-539
Understanding the Manufacturing Process of Lipid Nanoparticles for mRNA Delivery Using Machine Learning Read more
Editor's pick

Lipid nanoparticles (LNPs) are crucial for mRNA medicine as they protect and deliver mRNA into cells. The manufacturing process involves two steps: preparing LNPs (upstream) and removing ethanol and exchanging buffers (downstream). Typically, microfluidic devices and dialysis membranes are used for these processes. However, determining the effects of manufacturing parameters on LNP quality is challenging. Authors used extreme gradient boosting (XGBoost) to identify key parameters such as ethanol concentration, buffer pH, and flow rate, which impact particle size and encapsulation efficiency. Bayesian optimization was then applied to derive conditions for manufacturing LNPs of varying sizes. These findings will help improve the efficiency of mRNA-LNP manufacturing.

Volume 72 (2024) Issue 6 Pages 540-546
Three neo-Clerodane Diterpenoids from Tinospora cordifolia Stems and Their Arginase Inhibitory Activities Read more
Editor's pick

[Highlighted Paper selected by Editor-in-Chief]
Arginases I and II are Mn(II)-dependent hydroxylases that convert L-arginine into L-ornithine and urea in the urea cycle, and has been proposed as a potential therapy target for various illnesses, such as cardiovascular, anti-inflammatory, autoimmune, oncological, and infectious diseases. Herein, authors report the isolations and structural elucidations of three neo-clerodane diterpenoids, including two new tinocordifoliols A and B and one known tinopanoid R from the Tinospora cordifolia stems as well as their inhibitory activities against human arginase I. The assay revealed that tinopanoid R was a natural arginase I inhibitor in a competitive manner with respect to L-arginine.

Volume 72 (2024) Issue 6 Pages 566-569
Oxidative Coupling of Hydroquinone Derivatives with Olefins to Dihydrobenzofurans Read more
Editor's pick

The development of efficient synthesis of heterocyclic compounds is crucial important for drug discovery. Authors have newly developed the oxidative coupling of hydroquinones/4-aminophenols, bearing the electron-withdrawing groups, with various olefins (styrenes, enol ethers, and allyl silane) to provide dihydrobenzofurans as important heterocyclic skeletons for bioactive compounds and natural products. For example, the oxidation of 2-methoxycarbonylhydroquinone using 2,3-dichloro-5,6-dicyano-p-benzoquinone and the following coupling with styrene in the presence of Lewis acidic FeCl3 could procced under the mild reaction conditions to give the corresponding dihydrobenzofuran product. This method can easily yield various dihydrobenzofurans that can contribute to drug discovery.

Volume 72 (2024) Issue 6 Pages 570-573
Total Synthesis of (+)-Silybin A Read more
Editor's pick

The authors achieved the first total synthesis of silybin A, a hybrid natural polyphenol with attractive biological activities. The highlight of the study includes modified Julia-Kocienski olefination reaction and Sharpless dihydroxylation, which enabled the highly stereocontrolled synthesis. Additionally, the acid-promoted generation of two types of quinomethide intermediates led to the biomimetic construction of both the 1,4-benzodioxane neolignane and the flavanol lignan core skeletons within silybin A. The high generality of this methodology would allow for the synthesis of a diverse array of structurally related silybins, isosilybins, and other hybrid polyphenols.

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  • Chem. Pharm. Bull. Vol. 71 No. 7
    Current Topics: Frontiers in Alzheimer's and Dementia Research
  • Chem. Pharm. Bull. Vol. 71 No. 3
    Current Topics: Progress in Electrochemical Analysis for the Pharmaceutical Sciences
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    Current Topics: Advanced Medicinal Chemistry in Academia