Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University

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27,637 registered articles
(updated on September 20, 2020)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
2019 Journal Impact Factor (JIF)
Scopus Pubmed
Featured article
Volume 68 (2020) Issue 9 Pages 823-831
Nonheme Iron- and 2-Oxoglutarate-Dependent Dioxygenases in Fungal Meroterpenoid Biosynthesis Read more
Editor’s picks

The fungal meroterpenoid biosynthetic pathways exhibit an abundance of unusual chemistries and interesting enzyme reactions, including those of the multi-functional non-heme Fe(II)- and 2-oxoglutarate-dependent oxygenases that perform selective C–H activation/functionalization with unusual substrate promiscuity and catalytic versatility. Structure–function studies of these remarkable enzymes provide an excellent platform for the development of useful biocatalysts for synthetic biology to create novel molecules for drug discovery.

Volume 68 (2020) Issue 9 Pages 832-836
Effect of Rubbing on the Distribution of Topically Applied Drugs into the Hair Follicles Read more
Editor’s picks

Rubbing actions are often conducted to apply topical formulations onto the skin. However, few studies have reported the reasons for the acceleration of drug permeation through skin after topical application with or without rubbing. In addition, no studies observed the effect of rubbing direction on the skin penetration-enhancement effects. In this paper, the authors investigated the effects of rubbing direction on the skin permeation and disposition of a model hydrophilic drug, caffeine. This paper provides useful information on the effect of rubbing action and rubbing direction on the skin permeation of topically applied drugs.

Volume 68 (2020) Issue 9 Pages 864-867
Iriomoteolides-14a and 14b, New Cytotoxic 15-Membered Macrolides from Marine Dinoflagellate Amphidinium Species Read more
Editor’s picks

Marine dinoflagellates are well known as rich sources of biologically active compounds possessing unique chemical structures. This paper deals isolation and structure elucidation of two new cytotoxic 15-membered macrolides, iriomoteolodes-14a and 14b, from the marine dinoflagellate Amphidinium species collected off Iriomote Island, Okinawa. The structures including the absolute stereochemistry of eight stereocenters were determined on basis of spectroscopic data and chemical conversion method. These compounds are analogous to known macrolides, amphidinolides O and P, and the biosynthetic relationships for four compounds are also described.

Volume 68 (2020) Issue 9 Pages 868-878
Collaborative Study to Validate Purity Determination by 1H Quantitative NMR Spectroscopy by Using Internal Calibration Methodology Read more
Editor’s picks

Quantitative nuclear magnetic resonance is a powerful tool in quantitative determination of the main component and impurities in a drug substance or a drug product because of its high accuracy, precision and efficiency. This method has the potential to establish metrological traceability easily and expected to be widely utilized for some compendial guidelines and official standards. In this study, the authors conducted an inter-laboratory comparison for qNMR methodology and confirmed that statistically qNMR has the competence to obtain the same quantification performance and accuracy as the conventional reliable methods.

Volume 68 (2020) Issue 9 Pages 885-890
Labeling of Peroxide-Induced Oxidative Stress Hotspots by Hemin-Catalyzed Tyrosine Click Read more
Editor’s picks

Tyrosyl radical generation plays a major role in hemin/peroxide-induced oxidative stress. The authors developed a method for trapping tyrosyl radicals using a derivative of N-methyl luminol, a tyrosine labeling reagent. The derivative selectively forms a covalent bond with tyrosine residue (tyrosine click reaction) under single-electron oxidation conditions. This reaction labels oxidative stress hotspots not only at the protein level but also at the level of tyrosine residues undergoing oxidation. The cover picture depicts an image of tyrosine click reaction to aid in the visualization of hemin/peroxide-induced oxidative stress generated in blood vessels.

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  • Chem. Pharm. Bull. Vol. 68 No. 7
    Current Topics: Recent Progress in Drug Delivery System for Cancer Therapy
  • Chem. Pharm. Bull. Vol. 68 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future