Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 15,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University
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27,949 registered articles
(updated on June 26, 2022)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
2020 Journal Impact Factor (JIF)
Scopus Pubmed
Featured article
Volume 70 (2022) Issue 6 Pages 420-426
Enhancing Anticancer Potency of a 13-Substituted Berberine Derivative with Cationic Liposomes Read more
Editor's pick

This paper reports the successful use of a cationic liposomal-encapsulated novel 13-substituted berberine derivative for the targeted cell uptake and delivery to the cancer cell nucleus. Additionally the liposome also assists with stabilization of the selectively toxic anticancer berberine derivative with respect to oxidative cleavage in solution.  Liposomes derived from a cholesterol-based lipid with a polar side chain which would become cationic after amine protonation, were of particular interest. Enhanced cancer cell toxicity was seen in vitro with the cationic liposomal formulation of the berberine derivative possibly via inhibitory interactions with the cell’s telomere/telomerase system.

Volume 70 (2022) Issue 6 Pages 435-442
Model Synthetic Study of Tutin, a Picrotoxane-Type Sesquiterpene: Stereoselective Construction of a cis-Fused 5,6-Ring Skeleton Read more
Editor's pick

This paper describes a stereoselective synthesis of a cis-fused 5,6-ring skeleton in picrotoxane-type sesquiterpenes. This bicyclic skeleton is a synthetic challenging structure because of the presence of multiple consecutive stereocenters including two tetrasubstituted carbons at the angular positions. The authors developed a synthetic method of the core structure via DL-proline-mediated intramolecular aldol reaction accompanied with the desymmetrization of the 2-methyl-1,3-cyclopentanedione moiety and the construction of four contiguous stereocenters. This reaction can be also applied to the kinetic resolution using L-proline, implying that the established method would be useful for the synthesis of natural products classified as picrotoxane-type sesquiterpenes.

Volume 70 (2022) Issue 6 Pages 448-453
Design, Synthesis and Cytotoxicity Evalufation of Substituted Benzimidazole Conjugated 1,3,4-Oxadiazoles Read more
Editor's pick

Many drugs being used in chemotherapy of cancer has nitrogen-containing heterocyclic moieties as their basic structure, and the authors extensively focused on the 1,3,4-oxadiazole and benzimidazole scaffolds. In this article, two series of novel hybrids combining the 1,2-disubstituted benzimidazole and 1,3,4-oxadiazole or thioether linked 1,3,4-oxadiazole were designed and successfully synthesized. The in vitro cytotoxicity bioassays came up with the discovery of three lead compounds which displayed 4.5-13 fold increase in activity compared to 5-FU against the three human cancer cell lines (HeLa, MCF-7, A549), meriting further characterization and serving as promising scaffolds in the discovery of new potent anticancer agents.

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Announcements from publisher
  • Chem. Pharm. Bull. Vol. 70 No. 1
    Current Topics: Liquid Chromatographic Techniques in Food Sciences
  • Chem. Pharm. Bull. Vol. 69 No. 10
    Current Topics: Analytical Chemistry in Biology and Medicine