Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 15,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University
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28,105 registered articles
(updated on June 06, 2023)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
2021 Journal Impact Factor (JIF)
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Featured article
Volume 71 (2023) Issue 6 Pages 435-440
Establishment of One-Pot Disulfide-Driven Cyclic Peptide Synthesis with a 3-Nitro-2-pyridinesulfenate Read more
Editor's pick

In peptide drug discovery, it is important to develop efficient synthetic methodologies to access cyclic disulfide peptides with the expression of functional activity and resistance to metabolic enzymes. In this study, the authors developed a one-pot disulfide-driven cyclic peptide synthesis. The entire process is carried out using solid phase peptide synthesis, thus eliminating complicated work up procedures to remove by-products and enabling production of high-purity cyclic peptides by simple cleavage of a peptidyl resin. Consequently, the one-pot synthesis of oxytocin as a model cyclic disulfide peptide was successfully accomplished using this method. Their study has contributed for the preparation of more complex and artificial disulfide peptides.

Volume 71 (2023) Issue 6 Pages 441-446
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence Read more
Editor's pick

Good adherence to medication is critical for successfully treating psychiatric disorders. The authors developed two types of aripiprazole gummies (ARP-Gs) with organoleptic masking, cocoa- and fruit-flavoured ARP-Gs using a commercially available ARP formulation. They evaluated the overall palatability and acceptability of the ARP-Gs by performing a gustatory sensation test in healthy volunteers. The both ARP-Gs exhibited superior palatability, and greatly exceeded the cut-off values of acceptability. The ARP-Gs could be alternative dosing forms in patients with schizophrenia, and pharmacists can prepare these formulations in pharmacies to enhance medication adherence and meet the specific needs of individual patients.

Volume 71 (2023) Issue 6 Pages 447-450
Substituent Effects at the N-Nitrosoaminophenol Moiety of a Photoinduced-Electron-Transfer-Driven Nitric Oxide Releaser Read more
Editor's pick

The authors have developed a series of photoinduced-electron-transfer-driven (PeT-driven) nitric oxide (NO) releasers that efficiently release NO upon irradiation with visible light. In this study investigating the substituent effects at the 2-position of the nitrosoaminophenol moiety, it was found that a methyl group had no significant effect on NO-releasing ability, while a nitro or methoxy group reduced it. The nitro group may suppress electron transfer to the antenna moiety, while the methoxy group may accelerate electron transfer but suppress deprotonation of nitrosoaminophenol. Understanding these structure-activity relationships could aid in further functionalizing PeT-driven NO releasers.

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Announcements from publisher
  • Chem. Pharm. Bull. Vol. 71 No. 6
    Current Topics: In Silico Technologies to Boost Pharmaceutical Development
  • Announcement of Academic Journals’ Awards Chemical and Pharmaceutical Bulletin (CPB)
  • Chem. Pharm. Bull. Vol. 71 No. 2
    Current Topics: Transition Metal Catalysis Research in Pharmaceutical Organic Chemistry
  • Chem. Pharm. Bull. Vol. 71 No. 1
    Current Topics: Applications of Fluorescence Detection in Current Pharmaceutical Research
  • Chem. Pharm. Bull. Vol. 70 No. 12
    Current Topics: Quality Evaluation of Crude Drugs Utilizing Chemometrics