Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 18,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University

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27,574 registered articles
(updated on May 29, 2020)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
2018 Journal Impact Factor (JIF)
Scopus Pubmed
Featured article
Volume 68 (2020) Issue 5 Pages 405-420
Development of Copper-Catalyzed Chemoselective Reactions Read more
Editor’s picks

“Soft” nature of copper catalysis enabled two types of chemoselective reactions. First, C-C bond forming reactions at an anomeric carbon of unprotected aldoses were developed by taking advantage of orthogonal reactivity between “soft” organocopper species and “hard” polar functional groups, free hydroxy groups. Second, preferential reaction between “soft” copper species and “soft” C-C multiple bonds enabled difunctionalization of the multiple bonds by controlling the reaction order of three reactive species. Well-controlled stereo- and/or regioselectivity of the reactions is another important feature of the copper catalysts.

Volume 68 (2020) Issue 5 Pages 436-442
Constituents of the Fruiting Body of Poisonous Mushroom Omphalotus japonicus Read more
Editor’s picks

Omphalotus japonicus (Tsukiyotake in japanese) is well-known as a poisonous mushroom in Japan. In this study, the authors isolated six new sesquiterpenes, four known sesquiterpenes and two known steroids from the fruiting body of O. japonicus with column chromatography, solid-phase extraction (SPE), and HPLC. The chemical structures were determined with NMR, MS and IR spectra. Relative configuration was determined with NOE correlations and absolute configuration was determined with ECD calculation. Three new compounds showed growth-restoring activity against mutant yeast via calcium-signal transduction.

Volume 68 (2020) Issue 5 Pages 452-465
Novel Indirect AMP-Activated Protein Kinase Activators: Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity Read more
Editor’s picks

This paper describes that the synthesis and evaluation of novel indirect adenosine monophosphate-activated protein kinase (AMPK) activators. The series of compounds selectively inhibited cell growth in several human breast cancer cell lines by activating AMPK. The back-up medicinal chemistry synthetic research on ASP4132, a previously reported clinical compound that acts as an indirect AMPK activator, led to the successful identification of 27b as a second-generation clinical candidate with promising profiles such as high aqueous solubility and less human Ether-a-go-go Related Gene (hERG) channel inhibitory activity.

Volume 68 (2020) Issue 5 Pages 466-472
Discovery of 1,3-Disubstituted 2,5-Diketopiperazine Derivatives as Potent Class I HDACs Inhibitors Read more
Editor’s picks

The 2, 5-diketopiperazine (DKP) scaffold exists in many natural product families, ranging from fungi and bacteria to the plant kingdom and mammals. Because of the privileged structure and the ability to bind vast receptors, it has become extremely attractive synthetic target for the assembly of natural product-like libraries for drug discovery. In this article, a series of novel derivatives containing DKP skeleton were developed as targeted inhibitors. Several compounds exhibited distinct HDAC1 inhibitory activities and showed antiproliferative activities against K562 and HL-60 tumor cell line.

Volume 68 (2020) Issue 5 Pages 473-478
Instrument-Dependent Factors Affecting the Precision in the Atomic Force Microscopy Stiffness Measurement of Nanoscale Liposomes Read more
Editor’s picks

Instrument-dependent factors affecting the precision in the atomic force microscopy stiffness measurement of nanoscale liposomes was examined. The tip shape evaluation method previously developed can be widely used via IC-mode force curve measurements as well as via QI mode. It was also revealed that spatial drift of the cantilever position was instrument-dependent factors which could affect the precision of liposome stiffness measurements in the case of IC-mode force curve measurement. These findings will promote the usage of the AFM stiffness measurement method for the characterization of lipid nanoparticle-based drug delivery systems.

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  • Chem. Pharm. Bull. Vol. 68 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future