The triangle contour diagram of the Hausner ratio (HR) was represented as a function of lactose (LAC), cornstarch (CS), and microcrystalline cellulose (MCC). The HR is given as the ratio of tapped density to bulk density of powders, and the value is often used as an index of powder fluidity. Although the fluidity of most formulations was acceptable, an increase in the amount of MCC led to poor fluidity (high HR values), which suggested that the upper limit of MCC was required to secure better fluidity of premix powders.
New Zn(II), Mg(II), Ni(II), Cu(II), Pd(II), and Ag(I) complexes of 2-trifluoroacetonylbenzoxazole ligand have been synthesized. Their structures were determined by single-crystal X-ray diffraction analyses. Some metal complexes have more antibacterial effects in comparison with the free ligand. Noticeably, the Ag(I) complex 2h exhibited low MIC value of 0.7 μM against Pseudomonas aeruginosa, which was even superior to Norfloxacin with that of 1.5 μM. 2h is bacteriostatic, exerts the cell surface damage observed by scanning electron microscopy and is less likely to develop resistance. 2h has been found to display effective antimicrobial activity against a series of bacteria.
The antioxidative activity of liposomes co-encapsulating stereoisomer 3S,3’S-astaxanthin (Asx-S) and α-tocotrienol (α-T3) was higher than the calculated additive activity, which results from intermolecular interactions between both antioxidants. The optimal Asx-S/α-T3 ratio for antioxidation was 1:2. Consequently, the Asx stereochemistry affects the intermolecular interaction of Asx/T3, and it was suggested that the intermolecular interaction caused a change in the electronic state of the Asx-S polyene moiety by the presence of double bond in the α-T3 triene moiety.
Abnormal uterine bleeding (AUB) induced by incomplete abortion, which is a common gynecological disease. Taohong Siwu decoction (TSD) has been developed to treat AUB for hundreds of years. In this study, it demonstrated that TSD significantly shortened the duration and reduced the quantity of uterine bleeding. These results suggested that TSD promoted endometrial repair and had a protective effect on uteri. The mechanism may be concerned with up-regulation of the levels of E2 and ERα expression.
Mirilactams C–E, Novel Polycyclic Macrolactams Isolated from Combined-Culture of Actinosynnema mirum NBRC 14064 and Mycolic Acid-Containing Bacterium
Released: June 01, 2018 | Volume 66 Issue 6 Pages 660-667
Shotaro Hoshino, Masahiro Ozeki, Chin Piow Wong, Huiping Zhang, Fumiaki Hayashi, Takayoshi Awakawa, Hiroyuki Morita, Hiroyasu Onaka, Ikuro Abe
Eremophilanes from Ligularia hookeri Collected in China and Structural Revision of 3β-Acyloxyfuranoeremophilan-15,6-olide
Released: June 01, 2018 | Volume 66 Issue 6 Pages 668-673
Yoshinori Saito, Yuko Shiosaki, Miho Fujiwara, Kanako Mihara, Hiromi Nakamizo, Kanako Otose, Yasuko Okamoto, Katsuyuki Nakashima, Ryo Hanai, Chiaki Kuroda, Xun Gong, Yosuke Matsuo, Takashi Tanaka, Motoo Tori