Studies on the Biosynthesis of Nucleic Acids. II. On the Role of Antimetabolites as an Inhibitor of Polynucleotide Biosynthesis

Abstract

The effect of 4-aminotriazole-5-carboxamide and certain purine antimetabolites (e.g. 8-azaguanine, 6-mercaptopurine, and 2, 6-diaminopurine) as well as folic acid antimetabolites (e.g. aminopterin) on the incorporation of labeled 4-aminoimidazole[4-¹⁴C]-5-carboxamide, formate-¹⁴C, and ³²P into polynucleotides of rat or pigeon liver slices was demonstrated and certain aspects of their mode of action were discussed.