Pharmaceutical Bulletin
Online ISSN : 1881-1345
Print ISSN : 0369-9471
ISSN-L : 0369-9471
Studies on Phenazines. XII. Synthesis of Methylphenazines with Sodium Amide
Yoshinori KIDANIHirotaka OTOMASU
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1956 Volume 4 Issue 5 Pages 391-395

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Abstract
Though the synthesis of methylphenazine derivatives has been reported, the yield was generally very poor. A variation of the improved Wohl-Aue reaction, carried out in the presence of sodium amide, gave better yield. The syntheses of 1- and 2- methyl- and 1, 6-dimethylphenazines and their oxides, as well as that of 1-methoxy- 6-methyl- and 1-methoxy-8-methylphenazines are described.
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© The Pharmaceutical Society of Japan
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