抄録
We present the cases of two girls with ovarian hyperandrogenism. They had clinical signs of hyperandrogenism: deep voice, hypertrichosis and amenorrhea. Case 1 was a 13-year-old girl with insulin receptor dysfunction suspected, because of a low dose of insulin utilization in the glucose clump test. Case 2 was an 11-year-old girl with polycystic ovary syndrome. In the two cases, OGTT showed impaired glucose tolerance and high serum concentration of IRI. HCG stimulation test revealed hypersecretion of testosterone probably from the ovary. A polycystic ovary or an enlarged ovary was detected by magnetic resonance imaging. We suggest that in these two cases the hypersecretion of testosterone from the ovary was associated with high serum IRI.
