A 9-Year-Old Girl Presenting Central Precocious Puberty with Polycystic Ovary Syndrome

Abstract

A 9-year-old girl presented central precocious puberty (CPP) with polycystic ovary syndrome (PCOS) simultaneously. She had obesity, hirsutism and acanthosis nigricans. Laboratory examination revealed high levels of serum LH, FSH (LH > FSH), testosterone and insulin. The response of dehydroepiandrosterone sulfate after administration of ACTH was normal for a female. She has been treated with GnRH analog and weight reduction. Excessive androgen production results from ovarian defect and therefore, functional ovarian hyperandrogenism and hyperinsulinemia might be major factor in the pathogenesis. This case is the first report of a PCOS woman demonstrating CPP simultaneously.