Frequencies of spontaneous breast development and spontaneous menarche in Turner syndrome in Japan

Toshiaki Tanaka; Yutaka Igarashi; Keiichi Ozono; Kenji Ohyama; Masamichi Ogawa; Hisao Osada; Kazumichi Onigata; Susumu Kanzaki; Hitoshi Kohno; Yoshiki Seino; Hiroaki Takahashi; Toshihiro Tajima; Katsuhiko Tachibana; Hiroyuki Tanaka; Yoshikazu Nishi; Tomonobu Hasegawa; Keinosuke Fujita; Tohru Yorifuji; Reiko Horikawa; Susumu Yokoya

doi:10.1297/cpe.24.167

Original Articles

Frequencies of spontaneous breast development and spontaneous menarche in Turner syndrome in Japan

Toshiaki Tanaka, Yutaka Igarashi, Keiichi Ozono, Kenji Ohyama, Masamichi Ogawa, Hisao Osada, Kazumichi Onigata, Susumu Kanzaki, Hitoshi Kohno, Yoshiki Seino, Hiroaki Takahashi, Toshihiro Tajima, Katsuhiko Tachibana, Hiroyuki Tanaka, Yoshikazu Nishi, Tomonobu Hasegawa, Keinosuke Fujita, Tohru Yorifuji, Reiko Horikawa, Susumu Yokoya

Author information

Toshiaki Tanaka
Tanaka Growth Clinic, Tokyo, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Yutaka Igarashi
Igarashi Children’s Clinic, Sendai, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Keiichi Ozono
Osaka University, Osaka, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Kenji Ohyama
University of Yamanashi, Kofu, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Masamichi Ogawa
Ogawa Clinic, Nagoya, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Hisao Osada
J.F. Oberlin University, Machida, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Kazumichi Onigata
Shimane University Faculty of Medicine, Izumo, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Susumu Kanzaki
Tottori University Faculty of Medicine, Yonago, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Hitoshi Kohno
Fukuoka Children’s Hospital, Fukuoka, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Present: Fukuoka Tokushukai Hospital, Kasuga, Japan
Yoshiki Seino
JCHO Osaka Hospital, Osaka, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Hiroaki Takahashi
Chiba City Ryoiku Center, Chiba, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Toshihiro Tajima
Hokkaido University School of Medicine, Sapporo, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Katsuhiko Tachibana
JCR Pharmaceuticals Co., Ltd., Ashiya, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Hiroyuki Tanaka
Okayama Saiseikai General Hospital, Okayama, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Yoshikazu Nishi
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Tomonobu Hasegawa
Keio University, Tokyo, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Keinosuke Fujita
Osaka City University, Osaka, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Tohru Yorifuji
Osaka City General Hospital, Osaka, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Reiko Horikawa
National Center for Child Health and Development, Tokyo, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan
Susumu Yokoya
National Center for Child Health and Development, Tokyo, Japan
Turner Syndrome Research Collaboration, Tokyo, Japan

Keywords: Turner syndrome, GH treatment, spontaneous breast development, spontaneous menarche, chromosome

JOURNAL OPEN ACCESS

2015 Volume 24 Issue 4 Pages 167-173

DOI https://doi.org/10.1297/cpe.24.167

Details

Abstract

The Growject® database on human GH treatment in Turner syndrome was analyzed in the Turner Syndrome Research Collaboration, and the relationships of the frequencies of spontaneous breast development and spontaneous menarche with karyotype and GH treatment were investigated. One hundred and three cases started GH treatment with 0.5 IU/kg/ week (0.5 IU group), and their dose was increased to 0.35 mg/kg/wk midway through the treatment course. Another 109 cases started GH at a dose of 0.35 mg/kg/wk (0.35 mg group). Spontaneous breast development was observed in 77 (36.3%) of the 212 patients, and spontaneous menarche occurred in 31 patients (14.6%). The frequency of spontaneous breast development was significantly lower in patients with the 45,X karyotype and significantly higher in patients with a structural abnormality of the second X chromosome. The frequency of spontaneous menarche was significantly higher in patients with mosaicism characterized by X monosomy and a cellular line with no structural abnormality of the X chromosome. No significant differences in frequencies of spontaneous breast development and spontaneous menarche were observed between the two dose groups, indicating that GH treatment does not increase the frequency of spontaneous puberty.

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