Clinical Pediatric Endocrinology
Online ISSN : 1347-7358
Print ISSN : 0918-5739
ISSN-L : 0918-5739
Original Article
Clinical practice guidelines for congenital hyperinsulinism
Tohru YorifujiReiko HorikawaTomonobu HasegawaMasanori AdachiShun SonedaMasanori MinagawaShinobu IdaTakeo YonekuraYoshiaki KinoshitaYutaka KanamoriHiroaki KitagawaMasato ShinkaiHideyuki SasakiMasaki Nio(on behalf of The Japanese Society for Pediatric Endocrinology and The Japanese Society of Pediatric Surgeons)
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2017 Volume 26 Issue 3 Pages 127-152


Congenital hyperinsulinism is a rare condition, and following recent advances in diagnosis and treatment, it was considered necessary to formulate evidence-based clinical practice guidelines reflecting the most recent progress, to guide the practice of neonatologists, pediatric endocrinologists, general pediatricians, and pediatric surgeons. These guidelines cover a range of aspects, including general features of congenital hyperinsulinism, diagnostic criteria and tools for diagnosis, first- and second-line medical treatment, criteria for and details of surgical treatment, and future perspectives. These guidelines were generated as a collaborative effort between The Japanese Society for Pediatric Endocrinology and The Japanese Society of Pediatric Surgeons, and followed the official procedures of guideline generation to identify important clinical questions, perform a systematic literature review (April 2016), assess the evidence level of each paper, formulate the guidelines, and obtain public comments.

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© 2017 by The Japanese Society for Pediatric Endocrinology

This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.
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