Abstract
Four hypogonadotropic men with GH deficiency impregnated their wives a total of seven times and fathered six normal children during the course of HCG-HMG treatment. One pregnancy resulted in an artificial abortion because of severe maternal hypertension. After cessation of GH therapy, HCG was administered at 3,000 IU i.m., 2 or 3 times a week for 6 months followed by the addition of 75 IU of HMG to each dose of HCG for 3 months. This regimen of HCG alone for 6 months and the combination of HCG and HMG for 3 months was repeated. In all of the patients, serum testosterone levels increased to the normal adult range within 6 months. The patients had sperm counts of 24-100 × 106/mL before they married. In conclusion, men with hypogonadotropic hypogonadism and GH deficiency were able to achieve spermatogenesis and to father children following our method of HCG-HMG treatment. Long-term HCG-HMG treatment is effective, even if a pretreatment HCG test is negative.
