抄録
In order to investigate whether cyproterone acetate improves growth in patients with idiopathic precocious puberty, we analyzed the final heights of 18 girls with this condition. They were treated with a mean dosage of cyproterone acetate of 112.5±26.3 mg/m2/d (75-165mg/m2/d) for a mean duration of 32.9±9.5M (12-51M). The mean chronological age at the start of the treatment was 7Y6M±1Y3M (5Y-9Y) and bone age was 9Y2M±1Y8M (6Y3M-12Y). At the end of treatment, chronological age was 10Y6M±4M (9Y10M-11Y5M), bone age was 12Y7M±1Y4M (9Y4M-14Y), height was 145.2±7.6cm (132.3-156.6cm) and height age was 11Y1M±1Y8M (7Y14Y6M). Their final height was 153.4±6.5 cm (141.2-164.5cm), SD score was -0.22±1.37 (-3±1.9), and growth after treatment was 8.3±3.5cm (1.7-14.1cm). The calculated target height using Ogata's method was 155.3±3.4cm (149.5-163cm). The difference between the final and target height was -1.7±5.8cm (10.5±7.5cm). These results indicate that cyproterone acetate treatment improves the final height in girls with idiopathic precocious puberty.
