Insulin-like Growth Factor-Binding Protein-1, A Marker of Insulin Production
1993 年 2 巻 Supple2 号 p. 51-55
詳細
1993 年 2 巻 Supple2 号 p. 51-55
The serum concentrations of IGFBP-1 are increased in patients with malnutrition, GH deficiency or type 1 diabetes whereas low levels are found in patients with acromegaly, obesity or type 2 diabetes, who are characterized by increased insulin production. The morning levels of IGFBP-1 can be used to predict the insulin response during hyperglycemic clamp since there is a significant inverse relation between these two variables. Determination of immunoreactive IGFBP-1 concentrations can be used as a diagnostic toolin the discrimination between type 1 and type 2 diabetes. It is proposed that the concentrationsof IGFBP-1 in serum are of importance for the availability of IGFs for the target tissues.
