Klinefelter Syndrome with Short Stature

Yuko Miki; Jiro Kagawa; Shinzo Egi; Masako Sawada; Hirohiko Ikegami; Takashi Arayama; Junko Ito; Shigeo Nagafuchi; Yutaka Nakahori; Yasuo Nakagome; Shigehiko Kamoshita

doi:10.1297/cpe.2.Supple2_99

Yuko Miki, Jiro Kagawa, Shinzo Egi, Masako Sawada, Hirohiko Ikegami, Takashi Arayama, Junko Ito, Shigeo Nagafuchi, Yutaka Nakahori, Yasuo Nakagome, Shigehiko Kamoshita

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Keywords: Klinefelter syndrome, 47, XXY karyotype, short stature, growth hormone neurosecretory dysfunction (GHND)

JOURNAL FREE ACCESS

1993 Volume 2 Issue Supple2 Pages 99-101

DOI https://doi.org/10.1297/cpe.2.Supple2_99

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Abstract

A case of Klinefelter syndrome (KS) is presented where the height SD score was -2.0 and the bone age was 7.0yr when the chronological age was 11.0yr. The patienthad a normal response to a GH stimulation test, but his mean GH secretion during sleep, the first morning-voided urinary GH and the plasma somatomedin-C (Sm-C) levels were abnormally low. It is likely that the patient's short stature resulted from GH neurosecretory dysfunction (GHND).

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