抄録
There are few reports about reactivation of gonadal function and progress through puberty after withdrawal of therapy with LHRH-A in patients with central precocious puberty (CPP). Eight patients (5 females and 3 males) with CPP were treated with LHRH-A (D-Ser6-LHRH) with a dose of 10μg/kg by single or twice daily subcutaneous injections for periods ranging from 3 to 5.3 years. We have studied 30-day consecutive patterns of first morning voided urinary gonadotropin and ovarian hormone excretion in these patients during and after withdrawal of therapy with LHRH-A. During the treatment, the mean and maximum concentrations of urinary LH and FSH in 7 patients studied were low. After withdrawal of therapy, a rapid resumption of puberty was observed in 3 patients, who also had a hypothalamic hamartoma. In the remaining 5 patients with idiopathic CPP, the testes increased rapidly in size in one boy; but among 4 girls, only 1 had regular menstruation and the other 3 had irregular or no menstruation. The urinary patterns of these hormones did not return quickly to a pubertal pattern after withdrawal of treatment in these girls. This may be partly related to the long-term use of LHRH-A, but seems to be partly caused by psychological factors. These patients treated with long-term LHRH-A will head follow-up and evaluation of the reproductive function.
