Abstract
In a screening test, children with insulin-dependent diabetes mellitus (IDDM)(n=24, 12.3±2.8 years) showed significantly lower levels of plasma 1, 5-anhydro-D-glucitol (AG) compared with normal control subjects (n=43, 11.0±2.3 years) and children having renal glucosuria (n=57, 11.6±2.5 years) (AG; 4.5±4.3 vs 25.8±11.9, 14.5±8.3μg/mL; P<0.01, respectively). A plasma AG level of 10.0μg/mL was found to have the most potential as a cutoff value for screening for diabetes (sensitivity 92%, specificity 89%).
We found a high correlation between plasma AG, fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1C), in IDDM children at the outpatient clinic (n=68, 12.2±5.2 years) (r=-0.72, -0.82, -0.73; P<0.01, respectively).
These findings suggest that the measurement of plasma AG might be useful for the detection of diabetes; however, AG determination can not be made more available than FPG and HbA1C in a screening test. On the other hand, the decrease in plasma AG observed in IDDM children with deteriorating glycemic control is probably too small for this to be used as an indicator at the outpatient clinic.
