An adult case of acute tubulointerstitial nephritis accompanied by uveitis (TINU syndrome: tubulointerstitial nephritis and uveitis syndrome)

Abstract

    TINU syndrome (tubulointerstitial nephritis and uveitis syndrome) is known as interstitial nephritis associated with uveitis, the cause of which is not clear so far. As most of the reports related with this disease were published by pediatricians and ophthalmologists, adult cases are not so common. We report on a case of a woman in her 40s suffering from TINU syndrome with fever, general fatigue and headache. We confirmed the diagnosis by a clinical course and the result of a renal biopsy. Blurry vision was apparent before the intake of loxoprofen sodium (a non-steroidal anti-inflammatory drug), the fact of which indicates that the beginning of the disease was before the intake of loxoprofen sodium. Although this syndrome is rare, patients with this syndrome may visit a clinic, hospital of rheumatologist, because a fever of unknown origin, joint pain and myalgia and so on can be the main symptoms of this syndrome. In this sense,rheumatologists should be aware of this disease.