Abstract
Objective: To analyze the relation between changes of anti-CCP antibody levels and disease activities of RA.
Patients and Methods: Anti-CCP antibody and IgM-Rheumatoid factor (RF) were measured twice in 101 patients with definite RA (16 male, 85 female). The average age of RA onset was 48.5±13.0 years and the average disease duration of RA at the first measurement was 8.7±9.6 years. The average interval between the two measurements was 5.4±1.1 years. DAS28-3CRP in each patient was calculated at the last measurement.
Results: Levels of anti-CCP antibodies and IgM-RF had no relation with disease activities of RA. Patients with a rising level of anti-CCP antibody showed significantly high DAS28-3CRP and poor treatment response compared to those without the antibody rising. Neither DAS28-3CRP nor treatment response differed significantly in changes of IgM-RF.
Conclusion: The DAS28-3CRP of anti-CCP antibody rising level was significantly higher than that of non rising level.
